MakeMKV for ripping, and use l33tmeatwad's AMVtool for encoding. It's meant for high quality h264 encodes in MP4 containers with fast paced animation, but that just means it'll easily handle anything else. Default settings should work for you.
Do not use Handbrake. It is bad bad bad bad.
If you really want full lossless, because you have TBs of space, you might consider encoding to UT Video or HuffYUV, which are lossless, but for that, I'd recommend a different process. If you don't mind storing in AVI, Avidemux 2.6 works well for this.
Please note, that unless your DVD is very recent, in that it is progressive and not interlaced, and the transfer quality is top notch, you might need to us filters to make the footage suitable for editing with.