My approach is similar to benny.
I used Mail on both machines, and you can choose not to add accounts on the work machine (and vice versa). Similarly, you do not need to activate messages, etc.
The challenge comes if you have apps store apps you want on your work machine, and how amenable your work is to purchasing any (i.e. not log into iCloud).
I only use iCloud, not dropbox or anything else now... (still have issues with contacts not syncing across my own devices, which I have not had time to look into)