I'll listen to The Talk Show is the guest is someone that I follow, otherwise it's a bit samey samey each week.
I used to listen to TWiT, MBW and The Ihnatko Almanac religiously but found MBW was a bit the same each week. Same with Andy Ihnatko.
Hello Internet is my favourite podcast. If you give it a whirl, definitely take the time to listen to it from the start.
I regularly listen to:
Topical (Russell Ivanovic of Shifty Jelly and Jelly)
Robot Or Not? (Which is Jason Snell and John Siracusa arguing about whether or not something's a robot)
Iterate (now defunct-ish)
Liftoff (Jason Snell and Stephen Hackett talking about space stuff)
Top Four (Marco Arment and his wife talking about their top four favourite things)
Material (Google-y podcast for people who don't use Android)
Reconcilable Differences (John Siracusa and Merlin Mann talking about how they became the grumpy old men they are today)
Cortex (Myke Hurley and CPG Grey (of Hello Internet))
The Pen Addict (it is what it sounds like)
Analogue (Casey Liss and Myke Hurley talk about feelings)